Southampton will need to show plenty of resilience, as well as a touch of ruthlessness, if they are to end Manchester City's perfect home record today.
Saints head to Etihad Stadium hoping to topple the Premier League champions, who have won all five of their top-flight matches on their own ground so far this term.
Hughes is fully aware of the size of the task, and says there is little margin for error.
"We've got to be resilient and able to stay in the game," he said. "Obviously, there's going to be periods when Man City are pressing and they've got momentum with them and we've got to be strong in those moments.
it's about making sure we're as good as we have been in recent weeks defensively and, if we're able to create clear-cut chances, we've got to take them.mark hughes
"I think in recent weeks, clearly with the confidence we've got from the two performances defensively and the clean sheets we've had of late, that's going to help us.
"We've got a number of fundamentals we've been working on, and they've obviously shown in our general defensive work in the last couple of weeks and that's pleasing, because it shows that guys are taking on the information and you can see they're getting more confident in terms of what we're trying to do, so we'll have to keep on building on that.
"Obviously, Man City will test us more than most, because arguably they are the best team in the league and, as a result, we've got to be very vigilant and make sure we don't give up easy chances, because clearly with the quality they have they will take them.
"So it's about us playing well, making sure that we're as good as we have been in recent weeks defensively and, obviously, if we're able to create clear-cut chances then we've got to take them."
Saints certainly gave City a real run for their money when the sides last met, on the final day of last season, losing in the last seconds of the game to a Gabriel Jesus goal which pushed Pep Guardiola's side past the 100-point mark.
"We need to get to that level. I thought on the day we were good value," said Hughes.
"It was unfortunate we went down to a last-minute goal, but we kept a very good team, who were desperate to win the game, at bay, and it was only in the last few seconds that they were able to breach our defence, so we've shown the capacity to be able to cause them problems and frustrate them, so hopefully we'll be able to remember that and make sure we take chances if we take them."